Big Green Diesel II - New Information About a Superior Manufacturing Process for Bio-fuel and its Tests Results from a Leading Research Laboratory
Green Air Energy of Texas Big Green Bio-diesel has tremendous value to the renewable energy market. Through the GAET process there is a significant cost savings to the refinery and end user, production times are greatly reduced, higher performance levels more ...
Unlock the Case for Renewable Energy - Study Reveals How Alternative Energy Will Impact the Economy More Efficiently Than the Keystone Pipline
For 200 years industrial civilization has relied on the combustion of abundant and cheap carbon fuels, but continued reliance has had perilous consequences. On the one hand, there is the insecurity of relying on the world's most unstable region more ...
New Energy Company Ready to Stimulate Jobs and the Economy ...Right Now!
The Physiological Functions of Proline Rich Polypeptides (PRP)
Proline Rich Polypeptides are extremely small chains of 10 amino acids or less, notably proline, that nonetheless have a very powerful effect in initiating and balancing our immune responses.
Proline Rich Polypeptides, also known as PRP, enhance the ability of thymus gland to release factors that help regulate immune functions in the body. Specifically, certain T cells, called TH1 helper cells, are antagonist to the activity of TH2 helper cells that promote certain functions of B lymphocytes. PRP can induce a shift from a predominantly humeral immune response to a more protective cellular response described as a "TH2 to TH1 shift".
Doing so may assist the immune system in more effectively fighting chronic viral and bacterial infections while simultaneously inhibiting the initiation of inappropriate inflammatory cascades associated with allergy, chemical sensitivity and auto-immune responses.
A more detailed list of the physiological functions of proline rich polypeptides follows.
Proline Rich Polypeptides are not species specific. PRP from bovine milk works on all mammals, including humans, dogs and cats33. As PRP is produced by all mammals and is an entirely natural product, it is generally thought to be safe for all ages. However, lactose is usually associated with PRP and therefore those with milk intolerance may need to proceed with caution. The addition of lactase, the milk sugar digesting enzyme, may ameliorate lactose intolerance.
Also, delicate immune system changes occur following conception and during pregnancy. Specifically, there is a shift to TH2 dominance to inhibit the mother's immune system from over responding to the different DNA of the new life now inside her. Although there are no known reports of colostrum's interference with full and normal gestation, until further investigation assures safety, BioPharma suggests pregnant women and women hoping to conceive should avoid PRP rich colostrum products unless suggested by their doctor.
To read more about this subject, click here.
To obtain related products, click here.
1) Zimecki, M, Artym, J. [Therapeutic properties of proteins and peptides from colostrum and milk] Post Higieny i Medycyny Doswiadczalnej 59:309-323 (2005).
2) Janusz, M, Staroscik, K, Zimecki, M, Wieczorek, Z, Lisowski, J. A proline-rich polypeptide (PRP) with immunoregulatory properties isolated from ovine colostrum. Murine thymocytes have on their surface a receptor specific for PRP. Archivum immunologiae et therapiae experimentalis (Warszava) 34(4):427-436 (1986).
3) Wieczorek, Z, Zimecki, M, Spiegel, K, Lisowski, J, Janusz, M. Differentiation of T cells into helper cells from immature precursors: identification of a target cell for a proline-rich polypeptide (PRP). Archivum immunologiae et therapiae experimentalis (Warszava) 37(3-4):313-322 (1989).
4) Bishop, GA, Haxhinasto, SA, Stunz, LL, Hostager, BS. Antigen-specific B-lymphocyte activation. Critical Reviews in Immunology 23(3):159-197 (2003).
5) Shi, M, Hao, S, Chan, T, Xiang, J. CD4+ T cells stimulate memory CD8+ T cell expansion via acquired pMHC I complexes and costimulatory molecules, and IL-2 secretion. Journal of Leukocyte Biology (2006).
6) Zimecki, M, Staroscik, K, Janusz, M, Lisowski, J, Wieczorek, Z. The inhibitory activity of a proline-rich polypeptide (PRP) on the immune response to polyvinylpyrrolidone (PVP). Archivum immunologiae et therapiae experimentalis (Warszava) 31(6):895-903 (1983).
7) Inglot, A.D, Janusz, M, Lisowski, J. Colostrinine: a proline-rich polypeptide from ovine colostrum is a modest cytokine inducer in human leukocytes. Archivum immunologiae et therapiae experimentalis (Warszava) 44(4):215-224 (1996).
8) Zablocka, A, Janusz, M, Rybka, K, Wirkus-Romanowska, I, Kupryszewski, G, Lisowski, J. Cytokine-inducing activity of a proline-rich polypeptide complex (PRP) from ovine colostrum and its active nonapeptide fragment analogs. European Cytokine Network 12(3):462-467 (2001).
9) Wieczorek, Z, Zimecki, M, Spiegel, K, Lisowski, J, Janusz, M. Differentiation of T cells into helper cells from immature precursors: identification of a target cell for a proline-rich polypeptide (PRP). Archivum immunologiae et therapiae experimentalis (Warszava) 37(3-4):313-322 (1989).
10) Julius, MH, Janusz, M, Lisowski, J. A colostral protein that induces the growth and differentiation of resting B lymphocytes. Journal of Immunology 140(5):1366-371 (1988).
11) See, DM, Khemka, P, Sahl, L, Bui, T, Tilles, JG. The role of natural killer cells in viral infections. Scandinavian Journal of Immunology 46(3):217-224 (1997).
12) Inglot, A.D, Janusz, M, Lisowski, J. Colostrinine: a proline-rich polypeptide from ovine colostrum is a modest cytokine inducer in human leukocytes. Archivum immunologiae et therapiae experimentalis (Warszava) 44(4):215-224 (1996).
13) Blach-Olszewska, Z, Janusz, M. Stimulatory effect of ovine colostrinine (a proline-rich polypeptide) on interferons and tumor necrosis factor production by murine resident peritoneal cells. Archivum immunologiae et therapiae experimentalis (Warszava) 45(1):43-47 (1997).
14) Domaraczenko, B, Janusz, M, Orzechowska, B, Jarosz, W, Blach-Olszewska, Z. Effect of proline rich polypeptide from ovine colostrum on virus replication in human placenta and amniotic membrane at term; possible role of endogenous tumor necrosis factor alpha. Placenta 20(8):695-701 (1999).
15) Kruzel, ML, Janusz, M, Lisowski, J, Fischleigh, RV, Georgiades, JA. Towards an understanding of biological role of colostrinin peptides. Journal of Molecular Neuroscience 17(3):379-389 (2001).
Alvarez-Thull, L, Kirkpatrick, CH. Profiles of cytokine production in recipients of transfer factors. Biotherapy 9(1-3):55-59 (1996).
17) Zablocka, A, Janusz, M, Rybka, K, Wirkus-Romanowska, I, Kupryszewski, G, Lisowski, J. Cytokine-inducing activity of a proline-rich polypeptide complex (PRP) from ovine colostrum and its active nonapeptide fragment analogs. European Cytokine Network 12(3):462-467 (2001).
18) Kubis, A, Marcinkowska, E, Janusz, M, Lisowski, J. Studies on the mechanism of action of a proline-rich polypeptide complex (PRP): effect on the stage of cell differentiation. Peptides 26(11):2188-2192 (2005).
19) Janusz, M, Lisowski, J. Proline-rich polypeptide (PRP)--an immunomodulatory peptide from bovine colostrum. Archivum immunologiae et therapiae experimentalis (Warszava) 41(5-6):275-279 (1993).
20) Pizza, G, Meduri, R, De Vinci, C, Scorolli, L, Viza, D. Transfer factor prevents relapses in herpes keratitis patients: a pilot study. Biotherapy 8(1):63-68 (1994).
21) Pizza, G, Viza, D, De Vinci, C, Palareti, A, Cuzzocrea, D, Fornarola, V, Baricordi, R. Orally administered HSV-specific transfer factor (TF) prevents genital or labial herpes relapses. Biotherapy 9(1-3):67-72 (1996).
22) Meduri, R, Campos, E, Scorolli, L, De Vinci, C, Pizza, G, Viza, D. Efficacy of transfer factor in treating patients with recurrent ocular herpes infections. Biotherapy 9(1-3):61-66 (1996).
23) Prasad, U, bin Jalaludin, MA, Rajadurai, P, Pizza, G, De Vinci, C, Viza, D, Levine, PH. Transfer factor with anti-EBV activity as an adjuvant therapy for nasopharyngeal carcinoma: a pilot study. Biotherapy 9(1-3):109-115 (1996).
24) Raise, E, Guerra, L, Viza, D, Pizza, G, De Vinci, C, Schiattone, ML, Rocaccio, L, Cicognani, M, Gritti, F. Preliminary results in HIV-1-infected patients treated with transfer factor (TF) and zidovudine (ZDV). Biotherapy 9(1-3):49-54 (1996).
25) Ferrer-Argote, VE, Romero-Cabello, R, Hernandez-Mendoza, L, Arista-Viveros, A, Rojo-Medina, J, Balseca-Olivera, F, Fierro, M, Gonzalez-Constandse, R. Successful treatment of severe complicated measles with non-specific transfer factor. In Vivo 8(4):555-557 (1994).
26) Orzechowska, B, Janusz, M, Domaraczenko, B, Blach-Olszewska, Z. Antiviral effect of proline-rich polypeptide in murine resident peritoneal cells. Acta Virologica 42(2):75-78 (1998).
27) van Hooijdonk, AC, Kussendrager. KD, Steijns, JM., In vivo antimicrobial and antiviral activity of components in bovine milk and colostrum involved in non-specific defense. British Journal of Nutrition 84(Suppl 1):S127-34 (2000).
28) Ushijima, H, Dairaku, M, Honnma, H, Mukoyama, A, Kitamura, T. [Immunoglobulin components and anti-viral activities in bovine colostrum] Kansenshogaku Zasshi 64(3):274-279 (1990).
29) Ablashi, DV, Levine, PH, De Vinci, C, Whitman, JE, Jr, Pizza, G, Viza, D. Use of anti HHV-6 transfer factor for the treatment of two patients with chronic fatigue syndrome (CFS). Two case reports. Biotherapy 9(1-3):81-86 (1996).
30) De Vinci, C, Levine, PH, Pizza, G, Fudenberg, HH, Orens, P, Pearson, G, Viza, D. Lessons from a pilot study of transfer factor in chronic fatigue syndrome. Biotherapy 9(1-3):87-90 (1996).
31) Chan, MC, Cheung, CY, Chui, WH, Tsao, SW, Nicholls, JM, Chan, YO, Chan, RW, Long, HT, Poon, LL, Guan, Y, Peiris, JS. Proinflammatory cytokine responses induced by influenza A (H5N1) viruses in primary human alveolar and bronchial epithelial cells. Respiratory Research 6:135 (2005).
32) Keech, A. Unpublished data. (2006).
33) Khan, A. Non-specificity of transfer factor. Annals of Allergy 38(5):320-322 (1977).